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The protective effect of losartan in the nephropathy of the diabetic rat includes the control of monoamine oxidase type A activity.
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Losartan potassium tablets are indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients.
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With oral administration of candesartan cilexetil, conversion to the active compound occurs rapidly and completely during gastrointestinal absorption.
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Antihypertensive effects of losartan potassium have been established in hypertensive pediatric patients aged 6 to 16 years.
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Losartan potassium is a white to off-white powder with a molecular weight of 461.
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Furthermore, a 50% reduction in albuminuria was seen twice as often in the group that received 300 mg of aliskiren daily as in the group that received placebo.
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The cumulative incidence of heart failure, cardiac arrhythmias, and peripheral artery disease was lower with candesartan than losartan (, panels a, b, and c).
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The patients were examined 13, 12, 8, 4, and 2 weeks before randomization; at the time of randomization; and 1, 4, 8, 11, 12, 16, and 24 weeks after randomization.
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Treatment with Losartan also reduced the occurrence of sustained doubling of serum creatinine by 25% and ESRD by 29% as separate endpoints, but had no effect on overall mortality (see Table 4).
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Although the maximum observation period was 108 months, the x axis for the plots was truncated at 96 months because of low number of observations after this time.
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AUCs) for losartan and its active metabolite were approximately 66 and 26 times the exposure achieved in man at the maximum recommended human daily dosage (100 mg).
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Compared to normal subjects the total plasma clearance of Losartan in patients with hepatic insufficiency was about 50% lower and the oral bioavailability was about doubled.
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