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Furthermore, a 50% reduction in albuminuria was seen twice as often in the group that received 300 mg of aliskiren daily as in the group that received placebo.

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The cumulative incidence of heart failure, cardiac arrhythmias, and peripheral artery disease was lower with candesartan than losartan (, panels a, b, and c).

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The patients were examined 13, 12, 8, 4, and 2 weeks before randomization; at the time of randomization; and 1, 4, 8, 11, 12, 16, and 24 weeks after randomization.

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Treatment with Losartan also reduced the occurrence of sustained doubling of serum creatinine by 25% and ESRD by 29% as separate endpoints, but had no effect on overall mortality (see Table 4).

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Although the maximum observation period was 108 months, the x axis for the plots was truncated at 96 months because of low number of observations after this time.

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AUCs) for losartan and its active metabolite were approximately 66 and 26 times the exposure achieved in man at the maximum recommended human daily dosage (100 mg).

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Compared to normal subjects the total plasma clearance of Losartan in patients with hepatic insufficiency was about 50% lower and the oral bioavailability was about doubled.

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